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The Best Bed Bug Treatment - 2022

Last updated on March 8, 2022

We looked at the top 10 and dug through the reviews from 21 of the most popular review sites including and more. The result is a ranking of the best .

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Our Picks For The Top

Show Contents
Our Take
Experts Included
Pros
Cons
  Top Pick

Ortho Home Defense Max Bed Bug Killer, 1-Gallon

Don't Waste Your Money Seal of Approval

Ortho

Home Defense Max Bed Bug Killer, 1-Gallon

Overall Take

Packs Plenty of PowerThis concentrated formula helps you ensure you do the job right the first time.

Experts Included
DWYM Home Experts plus My Move, Pest Control Hacks. Along with user reviews from Amazon, Home Depot and Walmart.
Pros
" Its handy wand applicator makes reaching nooks and crannies easy. It can also be used as a spot treatment"
Cons
"Can be harmful to humans."
  Runner Up

EcoRaider Natural Bed Bug Killer, 16-Ounce

EcoRaider

Natural Bed Bug Killer, 16-Ounce

Overall Take

Handy BottleThis 16-ounce bottle slides easily into tight spaces, making it easy to keep handy between uses.

Experts Included
DWYM Home Experts plus BestReviews, Pests, Pest Control Hacks, Sleepopolis, Scary Mommy, The Sleep Judge. Along with user reviews from Amazon and Walmart.
Pros
" Natural product that kills bed bugs with 100% efficacy. Dermatogically safe to use child and pet friendly."
Cons
"Some may be sensitive to the smell, varying results of efficacy and ingredients ,ay cause sensitivity."
  We Also Like

HARRIS Odorless Bed Bug Killer, 1-Gallon

HARRIS

Odorless Bed Bug Killer, 1-Gallon

Overall Take

Long-Lasting FormulaThis spray features a formula that continues to eliminate pests for up to 16 weeks.

Experts Included
DWYM Home Experts plus BestReviews, Pest Samurai, My Move, Pest Policy. Along with user reviews from Amazon.
Pros
" Kills even the strong persistant bugs and their eggs when sprayed directly. Safe to use in homes and around children. Provides up to 16 weeks of residual protection after treatment"
Cons
"Requires multiple treatments to be effective."
  Strong Contender

MGK Crossfire Insecticide Concentrate Bed Bug Killer, 13-Ounce

MGK

Crossfire Insecticide Concentrate Bed Bug Killer, 13-Ounce

Overall Take

Fast ActingWithin minutes of application, this spray begins to kill both bed bugs and their eggs.

Experts Included
DWYM Home Experts plus Find This Best. Along with user reviews from Amazon and Walmart.
Pros
" Easy to mix and quick to stop and kill. It's formulated kill Parathyroid resistant bed bug strains at all stages including eggs."
Don't just take for granted what one reviewer says. Along with our own experts, DWYM analyzes the top expert reviews of the leading products and generates a score you can actually trust.
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Products Considered

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Products Analyzed

We then selected the leading and most popular products for our team to review.

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21

Expert Reviews Included

In addition to our expert reviews, we also incorporate feedback and analysis of some of the most respected sources including: Insect Cop, Mom Junction, BestReviews, Plumbar Oakland, My Move.

243,117

User Opinions Analyzed

We also incorporate user reviews from the leading retailers including

Our experts reviewed the top 10 and also dug through the reviews from 21 of the most popular review sites including and more. The result is a ranking of the best of the best .

DWYM is your trusted roduct review source. Our team reviews thousands of product reviews from the trusted top experts and combines them into one easy-to-understand score. Learn more.

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Look for the DWYM seal for products that are the best in their category.

The Best Overall

Ortho Home Defense Max Bed Bug Killer, 1-Gallon


Our Expert Score

9.0
2 expert reviews

User Summarized Score

8.8
16,039 user reviews

Our Take

Designed to kill bed bugs, fleas and ticks, this spray is designed to attack both bed bugs and bed bug eggs for an all-inclusive solution. You can use this spray to spot treat your bed frames, mattresses and baseboards, among other areas. It comes with a continuous-spray wand that is easy and comfortable to hold while also helping get into tight spaces.

What other experts liked

Its handy wand applicator makes reaching nooks and crannies easy. It can also be used as a spot treatment
- My Move
Highly concentrated for killing even the toughest bed bugs and at an affordable price.
- Pest Control Hacks

What other experts didn't like

Lacks effectiveness and defective wand.
- My Move
Can be harmful to humans.
- Pest Control Hacks

Overall Product Rankings

1. Ortho Home Defense Max Bed Bug Killer, 1-Gallon

Overall Score: 9.5
Reviews Included: 7

2. EcoRaider Natural Bed Bug Killer, 16-Ounce

Overall Score: 9.4
Reviews Included: 8

3. HARRIS Odorless Bed Bug Killer, 1-Gallon

Overall Score: 8.8
Reviews Included: 8

5. Premo Guard Non-Toxic Bed Bug Killer, 24-Ounce

Overall Score: 8.5
Reviews Included: 4

6. Hot Shot 12-Ounce Bed Bug Fogger, 3-Pack

Overall Score: 8.4
Reviews Included: 5

8. Proof Plant-Based Bed Bug Killer, 16-Ounce

Overall Score: 7.6
Reviews Included: 5

9. Raid Foaming Bed Bug Killer, 16.5-Ounce

Overall Score: 7.0
Reviews Included: 5

10. Nix Non-Staining Bed Bug Killer, 5-Ounce

Overall Score: 6.9
Reviews Included: 3

Our Findings


Ortho Home Defense Max Bed Bug Killer, 1-Gallon

What We Liked: Designed to kill bed bugs, fleas and ticks, this spray is designed to attack both bed bugs and bed bug eggs for an all-inclusive solution. You can use this spray to spot treat your bed frames, mattresses and baseboards, among other areas. It comes with a continuous-spray wand that is easy and comfortable to hold while also helping get into tight spaces.


EcoRaider Natural Bed Bug Killer, 16-Ounce

What We Liked: Made from plant-extracted ingredients, this 16-ounce bed bug spray is great whether you’re dealing with a household infestation or bed bugs in one of your rental properties. You can use this to treat specific spots where bed bugs tend to hang out in your home. This spray is designed to treat even the bed bugs that resist pyrethroids.


HARRIS Odorless Bed Bug Killer, 1-Gallon

What We Liked: The formula is strong enough to kill bed bugs for months without being dangerous for household members and fabrics. Simply spray on affected areas and wait for it to do its job. You won’t have to worry about odors, and the formula is designed to kill even pyrethroid-resistant bed bugs and eggs.


MGK Crossfire Insecticide Concentrate Bed Bug Killer, 13-Ounce

What We Liked: You can spray this formula directly on mattresses for quick, efficient elimination of bed bugs and their eggs. The bottle contains concentrate that you mix with water for a solution that lasts. The easy-to-mix formula goes a long way, which means you can repeat treatment later as needed.


Premo Guard Non-Toxic Bed Bug Killer, 24-Ounce

What We Liked: While you’re treating your bed bugs, use this spray that’s designed to kill bed bugs directly. You’ll still need to treat, but this is great for getting rid of the bugs as you see them. The formula is made from all-natural ingredients so that you can feel safe using it around pets and family members.

Our Buying Guide

Bed bugs are an ongoing problem across the globe. In fact, if you travel often, you’re likely to encounter them at some point. The problem is, these invasive pests tend to hide in mattresses and box springs, where they remain unseen. You often don’t even know you have bed bugs until days after you’ve been bitten, when you see a series of small red bumps that itch.

If you suspect you might have bed bugs, it’s important to get the infestation under control before it becomes worse. Remove your bedding and search your mattresses for small red or rust-colored stains. This can be a sign that bed bugs have been crushed.

Also search for signs of live bed bugs. They’re small but easy to spot. As an infestation worsens, you’ll start to see them in the seams of furniture, under loose wallpaper and wall hangings and in drawer joints. They typically stay close to where people sleep.

Getting rid of bed bugs typically requires treating your surfaces with chemicals. Some choose to hire a professional to take care of it, but you can do it yourself with the right products. Make sure you research any product you buy to keep yourself and your home’s occupants, including pets, safe before you start treating.

It’s important to note that you might not completely eradicate bed bugs with one treatment. You may find you have to treat again in a few weeks or a couple of months. Don’t get rid of any spray you don’t use. Store at room temperature in a safe location of your house so you’ll have it on hand in case you see a reemergence of bed bugs.

With some bed bug treatments, you get a concentrate that you mix with water. This ensures your solution will last a while, giving you plenty of applications. But in most cases, you’ll need to use your mixed concentrate within hours of making it and dispose of any mixture that remains.

DWYM Fun Fact

Bed bugs have been around for centuries, but they weren’t prevalent in developed countries until the early 2000s. As pesticides were created to eliminate them, over time, they began to show immunity to some of those treatments, leading experts to go back to the lab to create a formula that could get rid of these new, more resistant breeds.

Although bed bugs can’t fly or jump, they have an uncanny ability to survive even without a food source. That allows them to hide out in dark places like mattresses and box springs for months without dying. They don’t tend to reside on humans long, but they might hitch a ride in your luggage while you’re traveling, making their way to your own home.

The Tips and Advice

  • Over time, some bed bugs have become resistant to pyrethrins and pyrethroids. It’s important to look for treatments that can help with the most stubborn bed bugs.
  • Bed linens should not be treated with chemicals. Instead, remove them and seal them in a plastic bag before laundering them and drying them at high temperatures to kill any bugs or eggs.
  • Some bed bug treatments are designed to tackle a variety of pests prone to bedroom infestations, including fleas and ticks. This can help you cover all your bases.
  • Don’t just treat your mattress and box frame if you feel you have bed bugs. Also check for bed bugs in your bed frame and on any bedside tables.
  • Look at the application process of a bed bug spray you’re considering. Some have a wand that makes application easy while others might require you to purchase a nozzle to dispense the formula.
  • You’ll likely end up with spray left over after you’ve taken care of your current infestation. Consider where you’ll store it. A smaller bottle might be more convenient.
  • If you’re concerned about chemicals, look for a spray that uses natural ingredients to eliminate bed bugs. Tea tree oil and lavender both eliminate bed bugs, especially when combined with other ingredients.
  • If you have a vacuum cleaner with a disposable bag, you can vacuum your bed bugs for an easy removal method. But you’ll need to seal the bag with tape, then wrap the vacuum bag in a bigger bag and seal it up tight before disposing of it to avoid another infestation.
  • Some bed bug sprays are designed to continue to work long after you spray them. That means you won’t have to continue to monitor and apply. If you go this route, though, make sure you’ve chosen an odorless, safe spray that will allow you to continue to sleep in your bed while it’s doing its job.

About The Author

Stephanie Faris 

Stephanie Faris is a novelist and professional writer. She lives in a beautiful one-acre home in the suburbs on the outskirts of Nashville. Her home and garden work has appeared on popular home sites. She's a true homebody and loves looking at new houses for sale for inspiration on her own home remodeling projects.